- RB Leipzig vs Atalanta
- Eintracht Frankfurt vs Barcelona
- West Ham vs Lyon
- Braga vs Rangers
The quarter-finals will begin on 7 April, with the return legs following a week later on 14 April.
The opening legs of the semi-finals will be played on April 28, followed by the return matches on May 5.
The final will be held on Wednesday, May 18 at the Ramón Sánchez-Pizjuán Stadium in Seville.